Pharmaceutica Analytica Acta

GEMS Wellington International School, Dubai, United Arab Emirates

Biography

Ryaan Datta is a student who participated in the Next Gen World Majlis event as a representative of GEMS Wellington International School. He was one of the students selected based on his responses to critical questions related to climate action and the United Nations' Sustainable Development Goals (SDGs). This initiative allowed students to engage with topics like climate change, sustainability, and global leadership, providing them with an opportunity to discuss these issues on a broader stage?

Publications

• Research Article   
  Optimizing Ultrasound Parameters for Targeted Blood-Brain Barrier Disruption: A Computational Approach
  Author(s): Ryaan Datta*
  
  The Blood-Brain Barrier (BBB) is a barrier between cranium and the neural tissues via blood, this barrier pose a significant challenge in treating brain diseases such as glioblastomas by restricting therapeutic agent delivery. This study explores the optimization of Focused Ultra Sound (FUS) settings to enhance BBB permeability, allowing localized delivery of treatments like Temozolomide (TMZ). Advanced simulation models, incorporating heterogeneity in vasculature and microbubble dynamics, were used to predict the optimal frequency, intensity and duration of FUS for safe and effective BBB disruption. The optimal settings 2.3333 MHz, 1.5 W/cm2 and a duration of five minutes were identified, minimizing collateral damage while achieving precise BBB disruption. However, these findings, though encouraging, require further validation to confirm their clinical .. View more»
  

  DOI: 10.35248/2153-2435.24.15.794

  Abstract HTML PDF