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Rutvi Vaja
Department of Biomedical Sciences and Research, School of Science Navrchana University, Vadodara, India
Publications
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Research Article
Gene Expression Meta-Analysis of Colon Rectal Cancer Tumour Cells Reveals Genes in Association with Tumourigenesis
Author(s): Rutvi Vaja*
Background: Every year, more than 12 million people are diagnosed with colorectal cancer (CRC), and more than 600,000 people die from it, making it second most deadly form of cancer.This work analyzes differential gene expression across CRC and other glandular tumour samples to identify expression changes potentially contributing to the development of CRC tumourigenesis. Methods: This work defines 13 gene signatures representing four CRC tumour and 10 other glandular tumours that are colonic by origin. Gene Set Enrichment Analysis (GSEA) is used to define positive and negative CRC gene panels from GSEA-identified leading-edge genes using two CRC signatures. GSEA then is used to verify enrichment and leading-edge gene membership of CRC panels in two independent CRC gene signatures. Analysis is then extended to four individu.. View more»