Biology and Medicine

Department of Animal Biology and Physiology, University of Yaounde I, Yaounde, Cameroon

Publications

• Research Article   
  Neuroprotective Effects of the Aqueous Extract of Leaves of Moringa oleifera (Moringaceae) in Scopolamine-Treated Rats
  Author(s): Sefirin Djiogue*, Ivana Youmbi Kammogne, Paul f. Seke Etet, Antoine Kandeda Kavaye, Franklin Zemo Gamo, Florette Motoum Tedjo, Rudig N. Djikem Tadah and Dieudonne Njamen
  
  Moringa oleifera Lam (Moringaceae) is a medicinal plant used in African traditional medicine against cognitive affections and metabolic diseases. In the present study, the memory-protective and neuroprotective effects of M. oleifera were assessed in scopolamine-treated rats. Wistar rats (n=48) were divided in 6 groups: A healthy control group and five groups treated daily with scopolamine (0.6 mg/kg, i.p.) for 14 days. Concomitantly, they received per os either distilled water (negative control), piracetam at 300 mg/kg (positive control), or aqueous extract of leaves of M. oleifera at doses 100, 200, or 400 mg/kg. Changes in animal cognition were assessed in the Morris Water Maze, in the last five days of treatment. Afterwards, the animals were sacrificed and brains dissected out and processed for biochemical and histopathological studies. Compared to the ne.. View more»
  

  DOI: 10.35248/ 0974-8369.22.14.474

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