Journal of Blood Disorders & Transfusion

Department of Hematology, All India Institute of Medical Science, New Delhi, India

Publications

• Case Report   
  PNH in a Child with Ringed Sideroblast-Diagnostic Riddle
  Author(s): Richa Juneja*, Gurpreet Sagoo, Priyanka Mishra and Renu Saxena
  
  Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired stem cell disorder presenting either with hemolytic or thrombotic event or co exists in patients with aplastic anemia and Myelodysplastic syndromes (MDS). These PNH clones have been shown to have prognostic and therapeutic implications. Flow cytometric analysis of GPI-linked proteins is the method of choice for diagnosis and it has replaced the acidified-serum lysis test (Hams test) and sucrose lysis test being quantitative and a more sensitive method. Occurrence of this PNH clones in pediatric patients is rare (10%) with few studies being reported. It can have varied clinical and haematological manifestations and should be considered in children especially in the setting of bone marrow failure causing cytopenia. We hereby present a rare case of child having hemolytic manifestation of PNH with cytopen.. View more»
  

  DOI: 10.35248/2155-9864.21.12.479

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