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Radheshyam Naik
Department of Translational Medicine and Therapeutics, Health Care Global Enterprises Ltd (HCG), Bangalore, India
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Research Article
A Correlation of Pathological Characteristics and Immunohistochemistry (IHC) Based Biomarker Expression in Triple Negative Breast Carcinomas
Author(s): KS Rajesh Kumar*, Priyanka Maheshwari, Diganta Hazarika and Radheshyam Naik
Background: Triple-Negative Breast Cancer (TNBC) is defined as a group of breast carcinomas that are negative for expression of hormone receptors Estrogen Receptor (ER) or Progesterone Receptor (PR) and Human Epidermal Growth Factor Receptor 2 (HER2). In India, several reports have suggested that TNBC incidence is higher and up to 31%. Histological features of triple-negative breast cancer are reported to be common with those of basal-like subtype, comprising of high-grade invasive ductal carcinoma, no special type, invasive ductal carcinoma with a large central a cellular zone, typical medullary carcinoma, and met aplastic carcinomas. In the present study, we aimed to correlate the pathological characteristics and evaluate IHC based expression of basal type biomarkers in triple negative breast carcinomas. Our study showed heterogeneity in histolo.. View more»