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Pushpam Kumar Sinha
Independent Researcher Vijayshree Complex, Kankarbagh, Patna, India
Publications
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Review Article
Does the Absence of Down-Regulation of MHC-I in Cancer Cells Necessarily Lead to their Annihilation by Immunologic Attack?
Author(s): Pushpam Kumar Sinha*
It has long been known now that MHC-I is down-regulated in several cancers and this has been linked with impaired immune attack against cancer cells. It is obvious then that low MHC-I expression is also linked with poor survival of cancer patients. But, however, through a careful analysis of the prognostic influence of MHC-I expression in colorectal cancer, head and neck squamous cell carcinoma, and biliary tract cancer, I conclude that the percentage of deaths of patients with high MHC-I expression in tumor (due to tumor alone) out of the total number of deaths (due to tumor alone) is not insignificant when compared to the percentage of deaths of cancer patients with low MHC-I expression in tumor. Hence the absence of down-regulation of MHC-I in cancer cells does not necessarily lead to their annihilation by immunologic attack. Stated differently, the down-regulation of MHC-I in canc.. View more»