Global Journal of Biology, Agriculture & Health Sciences

Departments of Pathophysiology, Guangxi Medical University, Guangxi, China

Publications

• Research Article   
  Construction of miRNAs and Gene Expression Profiles Associated with Ischemic Cardiomyopathy: Bioinformatics Analysis
  Author(s): Phong Son Dinh, Jun-Hua Peng, ChauMy Thanh Tran, Thanh Loan Tran and Shang-Ling Pan*
  
  Objective: Ischemic Cardiomyopathy (ICM) has ranked as the most common cause morbidity and mortality in the elderly over the past decades. One of the most important reasons for this is that its exact underlying mechanism remains poorly understood. Method: Five datasets were downloaded from the GEO database. Differential Gene Expression (DGE) was identified by the R RobustRankAggreg package. Differential miRNA expression was evaluated by the Limma package. Gene potential functions were then determined by the clusterProfiler database. The miRNA-DGE regulatory network was predicted by cyTargetLinker. Then, a protein-protein interaction network was constructed by STRING tool, MCODE, and BiNGO tool. Results: 91 miRNAs and 274 potential genes were identified. Of these, COL1A1, IGF1 and CCND1 were found to be involved in many.. View more»
  

  DOI: 10.35248/2319-5584.23.12.162

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