Department of Pediatrics, Children’s Hospital of Richmond at Virginia, Commonwealth University School of Medicine, Richmond, Virginia, USA
Dr Kum-Nji is a graduate of the University of Yaounde School of Medicine, Cameroon. He obtained an MPH from Tulane University, New Orleans, and subsequently did a pediatric residency from the Le Bonheur Children's Hospital Memphis, University of Tennessee. Dr Kum-Nji was in private practice for several years in rural Mississippi and Tennessee before joining academic medicine. Before joining the VCU school of Medicine, he previously taught in the University of Mississippi Medical School and the University of Pittsburgh School of Medicine.
Review Article
Group B Streptococcal Colonization and Intrapartum Antibiotics: Why a Vaccine is Urgently Needed
Author(s): Philip Kum-Nji*
The importance of global group B streptococcal (GBS) colonization during pregnancy is briefly reviewed in this
short article. About 20% all pregnant women worldwide are colonized with this organism necessitating the use of
intrapartum antibiotic prophylaxis (IAP) in order to prevent neonatal GBS disease. In some geographic regions rates
of colonization are as high as 35%. Such a high rate of IAP is shown to be concerning because of childhood adverse
effects. We briefly summarize 5 main childhood adverse outcomes from IAP which include antibiotic resistance,
the development of various atopic diseases, dysbyosis, obesity, and impaired immune function. Finally, the article
clearly lists 4 reasons why a GBS vaccine is specifically urgently needed in order to curb the often unnecessary if not
dangerous use of IAP to prevent against the onset of neonatal GBS disease. It.. View more»