Department of Critical Care Medicine, Forest University, Bogota, Colombia
Research Article
Rethinking D-dimer’s Role in the Diagnosis of Pulmonary Thromboembolism in Patients with COVID-19
Author(s): Nieto Estrada Victor Hugo*, Martinez Del Valle Anacaona, Valencia Moreno Albert Alexander, Molano Franco Daniel Leonardo, Calle Alvarez Elsy Sofia, Osorio Perdomo Daniela, Castaneda Ramirez Carlos Hernan, Gonzalez Zarate Natalia Andrea, Jaramillo Caceres Dayang Sulai and Bernal Salazar Tatiana Andrea
Background: D-dimer is a non-specific inflammatory marker that elevates in infections, thrombosis, and pregnancies.
COVID-19 is a prothrombotic inflammatory disease, and it is common to find elevation of D-dimer in severe
COVID-19 cases. The usefulness of D-dimer for the diagnosis of Pulmonary Thromboembolism (PE) in SARS CoV-
2 has not been determined.
Objective: To determine the operational characteristics of D-dimer as a diagnostic method for PE in patients with
COVID-19 treated at a university hospital in Bogotá, Colombia.
Methods: Study of diagnostic tests that included data from patients with COVID-19 with suspected PE who were
screened with the index test (D-dimer measured by turbidimetric immunoassay technique) and reference test
(Angiotomography of pulmonary arteries).
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