Research Unit of Microbiology and Antimicrobial Substances, Department of Biochemistry, University of Dschang, P.O. Box 67, Dschang, Cameroon
Norbert Kodjio Research Unit of Microbiology and Antimicrobial Substances, Department of Biochemistry, University of Dschang, P.O. Box 67, Dschang, Cameroon intrested in microbiology, antimicrobial substance and biochemistry.
Research Article
Evaluation of the Acute and Sub-chronic Toxicity of the Ethanolic Extract of Curcuma longa (Zingiberaceae) in Wistar Albino Rats
Author(s): Donatien Gatsing*, Gabriel Tchuente Kamsu, Simeon Pierre Chegaing Fodouop, Richard Simo Tagne, Norbert Kodjio and Adolette Lesly Nguelebek Fakam
Background: Commonly called "two hundred diseases" in Western Cameroon, Curcuma longa is a plant widely used
in traditional medicine for many years. In order to evaluate the safety of this plant commonly use in the treatment
of typhoid fever in Cameroon, the acute and Sub-chronic toxicity of the ethanolic extract of Curcuma rhizomes has
been studied in albino rats of Wistar strain.
Materials and methods: Acute and sub-acute toxicity of this extract were study using OCDE 2008 guidelines.
Results: The physical parameters were recorded during the experiment and the hematological and biochemical
parameters, as well as the histology of the liver and reproductive organs were carried out at the end of the experiment.
The acute toxicity study revealed no toxic effects, no behavioural disturbances an.. View more»