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NN Tupitsyn
Department of Immunology, National Medical Research Center of Oncology, Moscow, Russia
Publications
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Review Article
Azoximer Bromide as an Activator of Cellular Immunity: New Opportunities for Practical Use in Cancer Patients
Author(s): L Yu Grivtsova*, NA Falaleeva and NN Tupitsyn
In this review, we have summarized the data on the new properties and uses of Azoximer Bromide (AB) in cancer patients. Recent studies have shown that AB, an immunomodulator with immunoadjuvant properties, can have a direct antitumor effect through a number of mechanisms leading to the activation of both cellular and humoral immune responses. Azoximer bromide mediates the transcription of cytosolic helicase receptor MDA5 gene and acts as a modifier of the innate immune response and inducer of the RIG-I/MDA5 signaling pathway, mainly due to its effect on MDA5. AB inhibits the accumulation of the Myeloid-Derived Suppressor Cells (MDSC) population in experimental aseptic inflammation conditions. AB reduces extracellular neutrophil traps formation in in vitro studies. Azoximer bromide enhances the expression of the costimulatory molecule ICOSL by 1.7 and incr.. View more»