Department of Zoology, Tanta University, Tanta, Egypt
Research Article
The Helpful Effect of Vitamin D and Coconut Oil in Modulating the Histological Disorders of the Splenic Tissue in Hyperglycemic Mice
Author(s): Nabila I El-Desouki*, Mohamed L Salem, Dalia F Afifi, Nasef M and Faten M Abdallah
The present study aims to study the effect of Vitamin D (Vit D) or/and Coconut Oil (Coc) on the splenic histological changes of diabetic adult mice induced by STZ. The mice were divided into 7 groups, and the experimental duration was 4 weeks. Group I: Control group without any treatments; group II and group III: Non-diabetic groups orally received vitamin D in a dose of 500 IU (6.25 ml)/kg bw/d or Coc in a dose of 7.5 ml/kg bw/d; group IV: Diabetic group
injected IP with a single dose of STZ (200 mg/kg bw); groups V, VI and VII: Administration of vitamin D or Coc or both together to diabetic group. The results recorded: Group II and group III no significant changes in the Blood Glucose (BG), insulin splenic weight levels. Group IV had a significant increase in BG, significant decrease in insulin and splenic weight values. Group V recorded a modest decrease in BG, and a modest .. View more»