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Na Lin
Department of Cardiology, The Second Hospital of Jilin University, Changchun City, China
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Research
Proteomics Study of the Effect Left Atrial Appendage Resection on the Energy Metabolism of Atrial Muscle in Beagle Dogs with Rapid Atrial Pacing
Author(s): Chang Jing, Xing Yue, Na Lin, Cui Wenjing, Yu Ting* and Xue Xin*
Aims: The myocardial energy metabolism during Atrial Fibrillation (AF) a research hotspot. Proteomics provides a new method for the study of atrial fibrillation; however, there are no related studies of the effect of the Left Atrial Appendage (LAA) on the energy metabolism of the atrial muscle. We use proteomics to analyze the effect of resection of the LAA on the energy metabolism of the left atrial myocardial cells in beagle dogs with rapid atrial pacing. Methods: Nine beagle dogs were divided into three groups: the model group (rapid atrial pacing/LAA resection), the positive control group (rapid atrial pacing/LAA preservation), and the negative control group (sinus rhythm). Twelve weeks later, the atrial tissues were resected for proteomics study. Parallel Reaction Monitoring (PRM) was used for the validation of the targeted proteomics... View more»