Journal of Clinical & Experimental Pharmacology

Pakistan Society for Molecular and Clinical Hematology, Lahore, Pakistan

Publications

• Review Article   
  Genotype-phenotype Correlations in Inherited Cardiomyopathies, their Role in Clinical Decision-making and Implications in Personalized Cardiac Medicine in Multi-omics as Well as Disease Modelling Eras
  Author(s): Yaqob Samir Taleb*, Paras Memon, Aftab Jalbani, Nouf Al-Mutairi, Sarah Al-Mukhaylid, Nawaf Al-Anazi, Abdulkareem Al-Garni, Muneera Altaweel, Muhammad Aamir Khan, Muhammad Farooq Sabar and Zafar Iqbal*
  
  Inherited cardiomyopathies are a diverse group of heart muscle diseases caused by genetic mutations that result in structural and functional abnormalities of the myocardium. Understanding genotype-phenotype correlations in these conditions is vital for personalized cardiac medicine, enabling targeted therapeutic strategies and predictive diagnostics. This review explores the major types of inherited cardiomyopathies: Hypertrophic Cardiomyopathy (HCM), Dilated Cardiomyopathy (DCM), Arrhythmogenic Cardiomyopathy (ACM) and Restrictive Cardiomyopathy (RCM) and provides detailed insights into how different genetic mutations manifest as clinical features. The integration of multi-omics approaches and advanced disease modelling techniques has enhanced our ability to dissect these correlations. The review also discusses the implications of these findings for personalized me.. View more»
  

  DOI: 10.35248/2161- 1459.24.14.431

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