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Mubarak Alwadai
Thrombosis and Vascular Diseases Laboratory, RMIT University, Melbourne, Australia
Publications
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Research Article
The Association of Human Leukocyte DQB1*02:01 Allele with Foetus and Neonatal Alloimmune Thrombocytopenia
Author(s): Mubarak Alwadai and Denise E. Jackson*
Background: Foetal and Neonatal Alloimmune Thrombocytopenia (FNAIT) is a condition resulted from the destruction of foetal Human Platelet Antigen (HPA-1a) by maternal antibodies. HLA-DQB1*02:01 allele is implicated in FNAIT but did not draw much attention. We conducted this study to investigate the correlation of HLA-DQB1*02:01 to FNAIT. Study design and methods: We searched electronic databases to collect relevant studies (from inception to August 2021). Studies reported HLA-DQB1*02:01 genotype were included. HPA-1bb mothers who had confirmed FNAIT babies were called responders. HPA-1bb mothers who had been pregnant with HPA-1ab baby but did not develop FNAIT were called non-responders. Results: Five eligible studies were included. Data were extracted to generate forest plots which show Odds Ratio .. View more»