Biology and Medicine

Department of Internal Medicine and Clinical Hematology, Ain Shams University University, Cairo, Egypt

Publications

• Research Article   
  Prognostic Significance of Early Molecular Response in Patients Diagnosed with Chronic Myeloid Leukemia in Chronic Phase Treated with Nilotinib: A First-Line Therapy
  Author(s): Mohammad Abdallah Shazly*, Mohamed Osman Azzazi, Mohamed Abdelmooti Mohamed Samra and Ahmed Youssri Elsaed
  
  Background: Chronic Myeloid Leukemia (CML) is one of malignant hematologic disorders arises from hematopoietic stem cells. BCR-ABL transcript levels on the international scale at 3 and 6 months are defined as indicators of the early efficacy of first line TKI treatment. Aim To investigate the impact of Early Molecular Response (EMR; BCR-ABL ≤ 10% on the International scale at 3 or 6 months) on outcome of the newly diagnosed CML in chronic phase treated with Nilotinib. Patients and Methods: The study was enrolled from 2018 to 2020 at Nasser Institute for Research and Treatment. This is a prospective cohort study done on 94 newly diagnosed CML cases in Chronic Phase. Results: A statistically significant difference was detected between patients not achieved EMR with peripheral blasts ≥ 5%, whe.. View more»
  

  DOI: 10.35248/0974-8369.22.14.512

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