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Mina Lee
Department of Physics, Delft University, Germany
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Mini Review
Analyses of Single Molecule Torque and Twist Precision using Nanotechnology
Author(s): Mina Lee*
Unprecedented insights into the structure, purpose, interactions, and mechanical characteristics of biological macromolecules have been made possible by single-molecule manipulation techniques. Techniques that permit rotation and torque measurements, such the optical torque wrench (OTW) and several variations of magnetic (torque) tweezers have recently been added to the single-molecule toolset. Although single-molecule approaches' systematic evaluations of their location and force precision have garnered a lot of attention, they have received significantly less attention when it comes to their angle and torque precision. Here, we suggest using the Allan deviation as a technique to systematically quantify the precision of angle and torque measurements made on single molecules. We discover that both methods can produce torque accuracy when we apply the Allan variance method to exper.. View more»