Journal of Infectious Diseases and Diagnosis

Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

Publications

• Research Article   
  Non-Association of Visceral Adipose Macrophage Content, Body ,Mass Index and Inflammatory Markers in COVID-19
  Author(s): Steven H Su*, Yael R Nobel, Sepideh Besharati, Armando del Portillo, Michaela R Anderson and Daniel E Freedberg*
  
  Introduction: Adiposity, especially visceral adiposity with elevated Body Mass Index (BMI), is associated with a hyperinflammatory syndrome and poor outcomes in patients with COVID-19. In other diseases such as obesity, type 2 diabetes, and rheumatoid arthritis, systemic inflammation is driven directly by visceral adipose macrophages which release pro-inflammatory cytokines. Currently it is unknown whether visceral adipose tissue macrophage content may similarly explain the observation that COVID-19 patients with elevated BMI are at risk for a hyperinflammatory syndrome and death. Methods: This was a retrospective study of hospitalized adults who died of COVID-19 between March 2020 and June 2020 and underwent autopsy. Visceral adipose tissue macrophage content was quantified by histological staining of visceral adipose tissue samples with CD.. View more»
  

  DOI: 10.35248/2576-389X.23.08.232

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