Department of Molecular Biology, University of Oxford, Oxford, United Kingdom
Perspective
Clinical Trials on Mutations and their Abnormal Changes
Author(s): Michael Harrison*
The genome is composed of one or longer DNA molecules and mutations can occur anywhere in these molecules at any time. The most serious changes occur in genes, which are the functional units of DNA. Mutant forms of genes are called mutated alleles. Genes are usually composed of regulatory regions that turn on / off transcription of the gene at appropriate times during development, and coding regions that carry the genetic code of functional molecules, generally the structure of proteins. .. Proteins are primarily chains of hundreds of amino acids. Cells make 20 common amino acids. This is the unique number and sequence of these amino acids that give the protein its unique function. Each amino acid is three of the four possible base pairs of DNA (A–T, T–A, G–C, and C–G,)
Therefore, mutations that alter the DNA sequence can alter the amino acid sequence .. View more»