PMC/PubMed Indexed Articles
Indexed In
- Open J Gate
- Genamics JournalSeek
- JournalTOCs
- Ulrich's Periodicals Directory
- RefSeek
- Hamdard University
- EBSCO A-Z
- OCLC- WorldCat
- Publons
- Geneva Foundation for Medical Education and Research
- Euro Pub
- Google Scholar
Useful Links
Share This Page
Journal Flyer
Open Access Journals
- Agri and Aquaculture
- Biochemistry
- Bioinformatics & Systems Biology
- Business & Management
- Chemistry
- Clinical Sciences
- Engineering
- Food & Nutrition
- General Science
- Genetics & Molecular Biology
- Immunology & Microbiology
- Medical Sciences
- Neuroscience & Psychology
- Nursing & Health Care
- Pharmaceutical Sciences
Michael Freeley
School of Biotechnology, Dublin City University, Glasnevin, Dublin, Republic of ireland
Publications
-
Research Article
L-plastin Expression in HCT 116 Colorectal Cells Increases Migration and ROS in an NADPH Oxidase-Dependent Manner
Author(s): Eilis Foran, Michael Freeley and Aideen Long*
Objective: L-plastin is an action-bundling protein normally expressed in cells of haemopoietic origin but is also associated with malignant transformation. Aberrant expression of L-plastin expression correlates with tumour stage in colorectal cancers, and ectopic expression of L-plastin in colon cancer cell lines increases proliferation and migration. L-plastin is inducibly phosphorylated on Ser5 in response to a range of stimuli but the role of phosphorylated L-plastin in colon cancer cells has not been characterised. The aim of this study was to analyse the effect of L-plastin Ser5 phosphorylation on HCT 116 colon cancer cell proliferation and migration. Methods: Wild-type L-plastin or a Ser5 L-plastin mutant where serine was exchanged to a non-phosphorylatable alanine was expressed in HCT 116 cells. Cell p.. View more»