Biology and Medicine

Department of Blood and Shock Resuscitation, The United States Army Institute of Surgical Research, San Antonio, Texas, United States of America

Publications

• Research Article   
  Syndecan-1 and Thrombomodulin are Early Biomarkers for Development of Endotheliopathy in Trauma and Hemorrhagic Shock
  Author(s): Tiffani C. Chance*, Michael A. Meledeo, Andrew P. Cap, Daniel N. Darlington, James A. Bynum and Xiaowu Wu
  
  The causes of endotheliopathy are multifactorial and trauma dependent, and the temporal mechanistic link that it has with Acute Traumatic Coagulopathy (ATC) has yet to be fully determinutesed. Therefore, we sought to define early characteristics and markers of endotheliopathy in two rat models, a time-course of acute lethal hemorrhage shock and polytrauma with hemorrhagic shock, to answer the following questions: (1) How soon can elevated biomarkers of endotheliopathy be detected in non-survivable (decompensated) hemorrhagic shock; (2) Does extended hemorrhage time and accumulated hemorrhage impact biomarker levels; and (3) Does the addition of polytrauma contribute to the further elevation of said biomarkers? In this study, we delineated a significant, acute elevation in end plasma levels of syndecan-1, thrombomodulin, and heparan sulfate, whose shedding patterns are a function of ti.. View more»
  

  DOI: 10.35248/0974-8369.23.15.561

  Abstract HTML PDF