Journal of Allergy & Therapy

Department of Medical Sciences, University of Milan, Milan, Italy

Publications

• Research Article   
  The Local Toxicity of Cobalt Chrome Implants: A Systematic Review of Preclinical Studies
  Author(s): Ilaria E. Zais, Susanna Sammali, Matilde Pavan, Emanuele Chisari and Chad A. Krueger*
  
  Metal-on-metal total hip arthroplasty prostheses are known to release Cobalt and Chrome (CoCr) debris. The local accumulation of these ions and nanoparticles can cause adverse local tissue reaction, which can ultimately determine a negative outcome for patients. The aim of our systematic review was to report the latest evidence on the effects of CoCr particles on local soft tissue with a focus on its clinical relevance. PubMed, Embase, and Cochrane Library databases were screened to perform an extensive review. PRISMA guidelines were applied, and the risk of bias was assessed, as was the methodological quality of the included studies. 27 studies were included after applying the inclusion and exclusion criteria. 3 were human ex-vivo studies, 24 were preclinical studies, including 21 in vitro and 3 in animal models. The presence of metal ions results in cell damage by reducing cell viab.. View more»
  

  DOI: 10.35248/2155-6121.22.13.271

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