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Masaki Okumura
Department of Biotechnology and Life Sciences, Sojo University, Kumamoto, Japan
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Research Article
Photodynamic Therapy Effects of Hybrid Liposomes Including Indocyanine Green against a Xenograft Mouse Model Mice of Colorectal Cancer in vivo
Author(s): Hideaki Ichihara*, Masaki Okumura and Yoko Matsumoto
Aim: To examine the photodynamic therapy (PDT) effects of hybrid liposomes (HLs) composed of L-α- dimyristoylphosphatidylcholine (DMPC), polyoxyethylene (25) dodecyl ether (C12 (EO) 25), and indocyanine green (ICG) in human colorectal cancer cells (HCT116) in vitro and in vivo. Materials and Methods: HL/ICG composed of 89 mol% DMPC, 10 mol% C12 (EO) 25, and 1 mol% ICG were prepared by sonication. The inhibitory effects of PDT-HL/ICG in a subcutaneous xenograft mouse model of colorectal cancer were examined in vivo. Results: The inhibitory effects of HL/ICG irradiated with far-red light laser on the growth of HCT116 cells were observed. A remarkable reduction in tumor weight in xenograft mouse models intravenously treated with PDT-HL/ ICG after subcutaneous inoculation .. View more»