Journal of Vaccines & Vaccination

Department of Cardiology, Hospital Samaritano Higienópolis, United Health Group, Sao Paulo, Brazil

Publications

• Research Article   
  Predictors of QT Interval Prolongation in Critically-ill Patients with SARS-CoV-2 Infection Treated with Hydroxychloroquine
  Author(s): Frederico Scuotto*, Rogério Marra, Lilian Leite de Almeida, Mariana Santa Rita Soares, Gabriela Kurita Silva, Luiz Carlos Paul, Guilherme Drummond Fenelon Costa and Claudio Cirenza
  
  Background: Hydroxychloroquine (HCQ) has been described as a potential treatment for SARS-CoV-2 infection. However, there are safety concerns regarding its QT interval and pro-arrhythmic effects. Objective: This trial aimed to determine the predictors of QT interval prolongation and pro-arrhythmic effects in patients hospitalized for SARS-CoV-2 infection and receiving HCQ. Methods: We performed a retrospective observational study of 45 critically-ill patients hospitalized because of SARS-CoV-2 infection and treated with 800 mg of HCQ at day 1 and 400 mg on days 2–5. Clinical aspects and outcomes, basal and final corrected QT (QTc) interval, and the incidence of arrhythmias and arrhythmogenic death were observed. Independent predictors of QTc prolongation were identified using multivariable logistic regression.. View more»
  

  DOI: 10.35248/2157-7560.20.11.439

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