Journal of Nanomedicine & Nanotechnology

Department of Cell Biology, Institute of Biological Sciences, University of Brasília, Brazil

Biography

Dr. Marcelo Valle de Sousa is an Full Professor at the University of Brasília Marcelo Valle de Sousa. He also works at the Department of Cell Biology, Institute of Biological Sciences, University of Brasília, Brazil.

Publications

• Research   
  Formation of Protein Corona on Rhodium Citrate-Functionalized Magnetic Nanoparticles and Their Interaction with Human Macrophages
  Author(s): Weskly F Lago, Natália V de Carvalho, Natália L Chaves, Marina A Radicchi, Marcelo H Sousa, Wagner Fontes, Marcelo Valle de Sousa and Sônia Nair Báo*
  
  Nanoscience and Nanotechnology enable innovations for Medicine and for Biomedical Science. Among the current nanoparticles, maghemite associated with rhodium citrate (Magh-RhCit) has been shown to be promising, because it reduces side effects of drugs while maintaining cytotoxicity for tumor cells. However, NPs in contact with biological fluids are immediately coated by proteins (protein corona) that are unique to each nanomaterial. In this study, the adsorption of the most abundant binding proteins was studied in vitro using a three-step analysis: (1) characterization of the magnetic fluid (Magh-RhCit) before and after incubation with serum; (2) identification and physical and biochemical analysis of protein corona; and (3) the cellular internalization of these nanoparticles in human macrophages. Magh-RhCit was initially obtained in the magnetite phase (Fe3.. View more»
  

  DOI: 10.35248/2157-7439.19.10.534

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