Journal of Clinical & Experimental Pharmacology

Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India

Publications

• Research Article   
  Pharmacological Evaluations of Select Herbal Extracts on TLR7/8-induced Cytokine and Chemokine Production in Macrophage-like Cells
  Author(s): Manisha Dagar, Kamala Priya, Madhu Dikshit* and Ajay Kumar*
  
  Inflammation is an innate immune response triggered by harmful stimuli, such as pathogens, tissue injury, or toxins. The purpose is to eliminate the source of infection and initiate the healing process. However, an excessive acute inflammatory response can lead to severe and life-threatening complications, as seen during recent pandemics. In the context of viral infections, the activation of the TLR7/8 signaling pathway has been implicated in excessive cytokine secretion. In this study, we aimed to replicate the perturbed inflammatory environment resulting from the activation of the TLR7/8 specific agonists, imiquimod, and resiquimod. We utilized macrophage-like cells, as macrophages are the first responders during infections and secrete key pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β) to recruit immune cells to th.. View more»
  

  DOI: 10.35248/2161-1459.23.13.374

  Abstract HTML PDF