Department of Veterinary Medicine, Zootechnics and Physiology, Pharmacology, Universidad Nacional Autónoma de México and Avenida Universidad, Coyoacan, Mexico
Research Article
Study to Determine Bioequivalence of Three Ceftiofur Crystalline Free Acid in Pigs
Author(s): Luis Ocampo-Camberos, Minerva Monroy-Barreto, Agustín Nieto-Carmona, Juan Angel Jaime and Lilia Gutierrez*
Background: Antimicrobial resistance has the potential to affect sustainable development goals in food-producing
livestock. Poor quality antibacterial pharmaceutical preparations significantly contribute to heighten this problem.
Bioequivalence (BE) studies are very important for the development of dependable pharmaceutical preparations.
Methods: In this trial 3 Ceftiofur Crystalline Free Acid (CCFA) pharmaceutical preparations (1 reference and 2
experimental), intended for swine medicine and freely sold in Mexico, were tested to assess as to whether or not they
can be regarded as generic ones.
Results: Three commercially available products of CCFA containing 200 mg of ceftiofur crystalline free acid were
compared taking Excede® brand as reference preparation and preparations A and B as ex.. View more»