Journal of Pharmacovigilance

Department of Epidemiology, Jiangsu Institute of Planned Parenthood Research, Nanjing, China

Biography

Dr. Lei Ba  is an eminent researcher. Currently she is working in the Department of Epidemiology, Jiangsu Institute of Planned Parenthood Research, Nanjing, China.  Se has many publications. Her  area of expertise is Pharmacokinetics, Clinical Research, Pharmacovigilance,Pharmacokinetics.

Publications

• Research Article   
  A Disproportionality Analysis of the Risk of Rhabdomyolysis Associated with DPP-4 Inhibitors in the Food and Drug Administration Adverse Event Reporting System
  Author(s): Wenhui Shi*, Lei Ba and Zhiming Sun
  
  Backgrounds: Dipeptidyl peptidase 4 inhibitors (DPP4is) are widely used in patients with type 2 diabetes mellitus. Recently safety report from regulatory agency suggested DPP4is may be associated with rhabdomyolysis, thus we performed a detailed analysis and evaluated the association between DPP4is and rhabdomyolysis in the Food and Drug Administration Adverse Event Reporting System (FAERS). Methods: We examined the FAERS database from 2004q1 to 2017q3 (for a total of 9,906,642 reports), calculated the rates of rhabdomyolysis within the reports for DPP4is and reports for other drugs. After filtering concomitant drugs, we compared proportional reporting ratios (PRRs) among adverse events (AE) reports that listed DPP4is with and without these moderator drugs, to identify whether rhabdomyolysis is associated with the use of DPP4.. View more»
  

  DOI: 10.35248/2329-6887.20.8.295

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