Journal of Aging Science

Department of Pharmacology, LSU Health Science Center, New OrleansNew Orleans, USA

Publications

• Research Article   
  Angiotensin Converting Enzyme 2 (ACE2) Expression in the Aged Brain and Visual System
  Author(s): James M. Hill, Christian Clement, L. Arceneaux and Walter J. Lukiw*
  
  Multiple lines of evidence currently indicate that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) gains entry into human host cells via a high-affinity interaction with the angiotensin-converting enzyme 2 (ACE2) transmembrane receptor. Research has further shown the widespread expression of the ACE2 receptor on the surface of many different immune, non-immune and neural host cell types, and that SARS-CoV-2 has the remarkable capability to attack many different types of human-host cells simultaneously. One principal neuroanatomical region for high ACE2 expression patterns occurs in the brainstem, an area of the brain containing regulatory centers for respiration, and this may in part explain the predisposition of many COVID-19 patients to respiratory distress. Early studies also indicated extensive ACE2 expression in the whole eye and th.. View more»
  

  DOI: 10.35248/2329-8847.21.s7.001

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