Biology and Medicine

Guardant Health, Genomic Specialist, Medical Affairs, Redwood City, California, USA

Publications

• Short Communication   
  Retrospective Review of 374 Samples, Circulating DNA; As a Biomarker Assay to Support Clinical Management in Solid Tumors Treated with Multi Targeted Epigenetic Therapy (MTET)
  Author(s): Nezami M*, Klowsowski C and Hager SJ
  
  Here in this abstract we retrospectively review preliminary findings on 374 samples of circulating DNA extracted from 173 patients treated by multi targeted epigenetic therapy (MTET), which is a combination of natural histone deacetylase inhibitors and DNMT methyltransferase inhibitors. This therapy could dynamically interrupt the expression of altered genes, in a variety of solid tumor types, both in in vitro and in vivo models. We hypothesize that serial monitoring of the circulating DNA provides a feasible option for therapeutic decisions making based on presence of the driver genes in these cases. We also were able to track the antineoplastic response in these groups of patients by monitoring their tumor circulating DNA mutated allele fractions and propose a direct correlation with interim epigenetic therapy effectiveness. .. View more»
  

  DOI: 10.35248/0974-8369.20.12.462

  Abstract HTML PDF