Journal of Blood Disorders & Transfusion

Department of Clinical Immunology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

Publications

• Case Report   
  Genotyping of Blood Donors for Timely Procurement of Rare Antigen-Negative Blood: A Case Story of Acute HTR and Anti-Coa
  Author(s): Katrine Kielsen, Bibi Fatima Syed Shah Scharff, Anne Todsen Hansen, Line Malmer Madsen, Niels Erikstrup Clausen, Klaus Rieneck and Morten Hanefeld Dziegiel*
  
  Hemolytic Transfusion Reactions (HTR) caused by antibodies against the high-prevalence Coa antigen has rarely been reported, and Coa-negative Red Blood Cells (RBC) units are rare. A 74-year-old woman was admitted with gastro-intestinal bleeding and sepsis. She developed an alloantibody of unknown specificity after her first transfusion. After a third, urgent transfusion with a Coa incompatible RBC unit, she reacted with dyspnea, hypertension, cerebral impairment and ultimately cardiac arrest. Hemolysis was demonstrated, an anti-Coa was detected in her serum, and post transfusion investigations identified the implicated RBC unit as Co (a+b-). In the following weeks, the patient’s persistent need for RBC transfusions was met by fresh Coa-negative blood enabled by our recently imp.. View more»
  

  DOI: 10.4172/2155-9864.23.14.553

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