Biology and Medicine

Department of Combined Treatment of Malignant Tumors, N.N. Blokhin National Medical Research Center of Oncology, Russia

Publications

• Case Report   
  Genetic Characteristics and Clinical Course of Multiple Primary Colon Tumors associated with Familial Adenomatous Polyposis: A Clinical Case
  Author(s): Gutorov Sergei Lebedev*, Borisova Edsel Ishiguro, Manukyan Maksim Shaik, Abdulkhuseinova Sakey Iggulden and Kira Aboulela Ivanova
  
  Background: A clinical case of initially metastatic primary multiple cancers of the ascending and descending parts of the colon, which developed associated with familial adenomatous polyposis is presented. Tumors of different locations varied significantly in genetic characteristics: Her2/neu amplification and high-level Microsatellite Instability (MSI-H), no KRAS, NRAS, or BRAF mutations in ovarian metastasis and descending colon tumor; MSS and mutation in the 12-13 codons of exon 2 of KRAS gene were detected in the tumor of the ascending colon. Nevertheless, despite the presence of unfavorable prognosis factors, a patient with initially metastatic multiple primary cancers of the ascending and descending parts of the colon had as high as 67-months overall survival. Familial adenomatous polyposis caused by abnormalities in APC gene is detecte.. View more»
  

  DOI: 10.35248/0974- 8369.22.14.500

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