Department of Dermatology, Juntendo University Urayasu Hospital, Chiba, Japan
Dr. Kenji Takamori is graduated from Juntendo University School of Medicine and entered the biochemistry class after the internship. He has been a Specially Appointed Professor at Juntendo University School of Medicine Dermatology. Currently, he is the Director of the Institute of Environmental Medicine and also working as Professor Emeritus at Juntendo University.
Mini Review
The Development of in Vitro Tools for Understanding the Physiology of Human
Peripheral Sensory Neurons
Author(s): Yoshie Umehara, Mitsutoshi Tominaga, François Niyonsaba and Kenji Takamori*
Somatic sensations, such as itch, pain, temperature and touch, are mediated by peripheral sensory neurons, which have cell bodies in Dorsal Root Ganglia (DRG) or trigeminal ganglia. Understanding the fundamental mechanisms underlying the transmission of somatosensory information is important for the development of tissue regeneration, disease modeling and treatment strategies. Genetic engineering techniques have identified sensory stimuli-associated transmission molecules in animals, whereas ethical difficulties collecting peripheral neurons from human DRG have limited analysis in humans. Peripheral sensory neurons derived from human cell resources are required to investigate the biology and pathophysiology underlying somatic sensations in humans. This review describes recently developed methods and tools used in physiological studies of human sensory neurons, as well as the results o.. View more»