Gene Technology

Department of Immunogenetics, University of Nagasaki, Nagasaki, Japan

Biography

Dr Kenji Hirayama MD, PhD, is Professor and Vice Dean at the Institute of Tropical Medicine (NEKKEN), Nagasaki University, and Tokyo Medical and Dental University. He is Chairman of the Parasitic Disease Panel of the US-Japan Medical Cooperation Program, 2008-2016. He is Chairman of the Forum for Ethical Review Committees in Asia and Pacific Regions (FERCAP), 2010-present.

Publications

• Review Article   
  Immunogenetic Mechanisms of Black Water Fever: Article Review
  Author(s): Joseph M. Bodi*, Celestin N. Nsibu and Kenji Hirayama
  
  The authors systematically reviewed the literature on mechanisms of Black Water Fever ‘BWF) on immunology and genetics point of view to determine whether immunity and genetics are involved in the occurrence of Acute Intravascular haemolysis in malaria, leading to BWF.. All original reports of BWF were retrieved from Embase, Medline from 1935 to December 2018. Information extracted from each article included study design, definitions of BWF, pathogeny and risk factors of the disease. Descriptive, Prospective cohort, cross sectional, and case-control studies were assessed. Malaria IgG1 antibodies were measured. MBL2 gene were amplified and sequenced. BWF was associated to high level of malaria IgG1 antibodies. The geometric mean of antibodies in patients with BWF was high [1,95mg/l (IC95% :1,55-2,44) compared to [ 1,19 mg/l (IC95%: 0,98–1,43) ] in children with uncomplicated.. View more»
  

  DOI: 10.35248/2329-6682.21.10.160

  Abstract HTML PDF