Department of Respiratory Medicine and Allergology, Kindai University Nara Hospital, Japan
Research
The Effects of Switching from Fluticasone/Salmeterol Aerosol to Fluticasone/Formoterol Aerosol in Patients with Severe Asthma
Author(s): Soichiro Hanada, Ken Shirahase, Hirochiyo Sawaguchi, Masato Muraki* and Yuji Tohda
Objective: Two pressurized Metered Dose Inhalers (pMDIs) containing a combination of a corticosteroid and long acting β2 agonist: Fluticasone propionate/Salmeterol Combination (FSC), and Fluticasone propionate/Formoterol Combination (FFC), are currently available in Japan. In order to examine the usefulness of the FFC pMDI, we sought to investigate the efficacy, adverse events, and handling after switching to the FFC pMDI from the FSC in patients with asthma.
Methods: Fifty-six outpatients who were using the FSC pMDI (250/50 μg) twice daily were enrolled in the study. The following items were evaluated before and after the use of the FFC pMDI (250/10 μg) twice daily for 8 weeks: Asthma Control Test (ACT) Questionnaire; Asthma Health Questionnaire (AHQ)-33-Japan; spirometry; and forced
oscillation technique. On the final day of the study, the original questionn.. View more»