Journal of Data Mining in Genomics & Proteomics

Department of Gastroenterology and Hematology, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan

Biography

Dr. Keiichi Akizuki is an Associate professor in the Department of Internal Medicine, Miyazaki University, Japan. His study interests major on  Bioethics, Acupuncture. Currently, Dr. Keiichi Akizukig is the author/editor/reviewer in several international journals. He published 10 articles in many journals and the articles are informative and got good citations.

Publications

• Short Commentary   
  Short Commentary on TP53 and PTEN Mutations were shared in Concurrent Germ Cell Tumor and Acute Megakaryoblastic Leukemia
  Author(s): Keiichi Akizuki, Takuro Kameda, Kotaro Shide and Kazuya Shimoda*
  
  Concurrent mediastinal Germ Cell Tumors (mGCTs) and hematological malignancies in the same patient have been reported in 2-3% of extragonadal GCT cases. In most cases, the involved GCTs are non-seminomatous and mediastinal, while the Hematological Malignancies (HMs) are often acute megakaryoblastic leukemia. Isochromosome 12p has been frequently detected in both tumors. Recently, two cases of concurrent mGCT and acute myeloid leukemia harboring TP53 and PTEN mutations were reported. We published our research article about the case of a 37-years old male patient with concurrent GCT and acute megakaryoblastic leukemia. Similar to previous studies, TP53 and PTEN mutations were shared in both tumors, in addition to the other seven shared mutations. This suggests that the concurrent occurrence of GCTs and HMs are associated with a common founding clone with a characteristic coexistence of .. View more»
  

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