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Kazumi Fujioka
Department of Radiology, Nihon University School of Medicine, Tokyo, Japan
Publications
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Review Article
Intradermal Nodular Fasciitis: A Review of the Current Genetic Analysis
Author(s): Kazumi Fujioka*
Erickson-Johnson suggested that USP6 transcriptional upregulation may be the driving force behind the high proliferative activity and growth and the consistent involution nature of Nodular Fasciitis (NF). The author previously reported the case series of NF and strongly suggested that proliferative findings of the margin of the nodule on US and pathological features are caused by the driving force of USP6 transcriptional upregulation from an established cytogenetic nature. Recently molecular analysis of USP6 gene rearrangements have been detected in the most of NF cases, while MYH9 gene has been identified as the most common USP6 partner. It is suggested that the identification of USP6 fusion partners for NF may contribute to understand the biological effect. As intradermal NF is a rare lesion, few cases with molecular g.. View more»