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Kazumi Fujioka
Department of Radiology, Nihon University School of Medicine, 30-1 Oyaguchi-kamicho Itabashi-ku, Tokyo 173- 8610, Japan
Publications
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Review Article
Mechanism of Oxaliplatin-Induced Sinusoidal Obstruction Syndrome along with Therapeutic Strategy
Author(s): Kazumi Fujioka*
Oxaliplatin is a backbone drug of many regimens for colorectal cancer and colorectal liver metastasis. Most frequent adverse effects in patients with oxaliplatin-based chemotherapy include the peripheral neuropathy, liver dysfunction, splenomegaly, and thrombocytopenia. Recently, the author described a thorough review of the literature on oxaliplatin-induced hepatic complications focusing on Sinusoidal Obstruction Syndrome (SOS), Nodular Regenerative Hyperplasia (NRH), and Focal Nodular Hyperplasia (FNH) in patients with colorectal cancer and colorectal liver metastasis and emphasized the Liver Stiffness Measurement (LSM), elasticity as a novel predictor reflecting splenomegaly by elastography. The underlying mechanisms of oxaliplatin-induced SOS include the activation of inflammation-related pathways, the activated cellular hypoxia, the upregulation of genes involved in coagulation s.. View more»