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Kazumi Fujioka
Department of Radiology, Nihon University School of Medicine, Tokyo, Japan
Publications
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Review Article
Oxaliplatin-Induced Sinusoidal Obstruction Syndrome: Liver Stiffness Measurement as a Novel Predictor by Elastography
Author(s): Kazumi Fujioka*
Oxaliplatin is an essential component of many chemotherapies protocol for colorectal cancer and colorectal liver metastasis. The use of oxaliplatin in patients with colorectal cancer has been associated with the occurrence of the vascular hepatic lesions such as Sinusoidal Obstruction Syndrome (SOS), Nodular Regenerative Hyperplasia (NRH), and Focal Nodular Hyperplasia (FNH). It is known that SOS impairs liver function and increases morbidity and mortality. Based on the comparison between Liver Stiffness Measurement (LSM) and splenic volume index, recent study indicated that measurement of elasticity using shear wave elastography may noninvasively predict oxaliplatininduced hepatotoxicity. The recent report also provided the usefulness of MR elastography (MRE) in diagnosing SOS and determining SOS severity without contrast materials in patients with colorectal can.. View more»