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Kazumi Fujioka
Department of Radiology, Nihon University School of Medicine, Tokyo, Japan
Publications
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Review Article
Association between Obesity and Hepatocellular Carcinoma along with Nitroglycerin-Mediated Vasodilation Study
Author(s): Kazumi Fujioka*
It is known that Non-Alcoholic Fatty Liver Disease (NAFLD) causes NAFLD-associated Hepatocellular Carcinoma (HCC) and obesity, Type 2 Diabetes Mellitus (T2DM), and Cardiovascular Disease (CVD) as co-morbidities of NAFLD also promote the development and progression of HCC. Previous study indicated that dysregulated metabolites, low grade inflammation, immunity, and autophagy in the tumor microenvironment play a crucial role of HCC progression in obesity status. In this article, the author reviewed the current knowledge of association between obesity and hepatocellular carcinoma along with nitroglycerin-mediated vasodilation study. In result, with respect to the association between obesity and atherosclerosis, obesity is low grade inflammatory status, suggesting that inflammation and/or oxidative stress as a causal factor may induce decreased Flow-Mediated Dilatation (FMD) and impaired .. View more»