Department of Radiology, Nihon University School of Medicine, Tokyo, Japan
Dr. Kazumi Fujioka is an professor in the Department of Radiology, Nihon University School of Medicine, Tokyo, Japan. Dr. Wang is the author/editors/reviewer in several international journals. He published 21 articles in many journals and the articles are informative and got good citations.
Review Article
Current Genetic Advances in NAFLD/NASH: Related Hepatocellular Carcinoma Along with Characteristic Clinical Manifestation
Author(s): Kazumi Fujioka*
Non-Alcoholic Fatty Liver Disease (NAFLD) is the common liver disease worldwide because of the increasing rates in
parallel to obesity and Type 2 Diabetes Mellitus (T2DM). Mechanically, lipid accumulation and insulin resistance
serve as the first hit, second hit is considered as inflammation and fibrosis in NAFLD. NAFLD is attributed to liverrelated
morbidity and mortality, there is also growing evidence that NAFLD is a multisystem disease and is associated
with hepatic (hepatocellular carcinoma: HCC) and extrahepatic (Cardiovascular Disease: CVD, Coronary Artery
Disease: CAD, and Chronic Kidney Disease: CKD) diseases. The author previously suggested that an association
between chronic liver disease (NAFLD/NASH and chronic hepatitis C virus infection: HCV infection) and systemic
atherosclerosis may be present due to the presence of the inflammation as a common pa.. View more»