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Kar Men Tee
Department of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia
Publications
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Research Article
The Effectiveness and Compliance of Routine Antenatal RhIG Prophylaxis using Different Strategies: A Systematic Review and Meta-analysis
Author(s): Kar Men Tee and Denise E Jackson*
Routine antenatal anti-D prophylaxis has successfully reduced the incidence of RhD alloimmunisation and Haemolytic Disease of the Foetus and Newborn (HDFN). However, there are different strategies and guidelines available across different countries. This systematic review and meta-analysis aimed to investigate the effectiveness and compliance of routine antenatal prophylaxis of different strategies by measuring detectable anti-D levels at delivery, RhD alloimmunisation rate and compliance. PubMed, SCOPUS, EMBASE and Cochrane Library were searched up until 30 July 2023. Binary random effects meta-analysis using maximum likelihood method was performed in Open Meta Analyst software. 17 studies were eligible for meta-analysis. More women had detectable anti-D at delivery after two-dose regimen (24.5%; estimate 0.532, 95% CI [0.181, 0.866], P<0.001) than one-dose regi.. View more»