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K. Herynkova
Department of Thin Films and Nanostructures, Institute of Physics, Academy of Sciences of the Czech Republic, Czech Republic
Biography
RN Dr. Katerina Herynkova, Ph.D. Scientist, Division of Solid State Physics. Department of Thin Films and Nanostructures, Institute of Physics, Academy of Sciences of the Czech Republic
Publications
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Research Article
Comparison of Si Nanoparticle types for use as a Potencial Drug Delivery System for Central Nervous System Diseases
Author(s): E. Podkorytov*, M. Stastny, M. Chvojkova, L. Cejkova, OH Asnaz, J. Benedikt, M. Muller, P. Galář, K. Valeš and K. Herynkova
Diseases affecting the central nervous systém (CNS) are considered to be some of the most debilitating conditions worldwide. The range of standard therapies for disorders affecting CNS is largely limited for many patients. Nonetheless, nanoparticle-based drug delivery offers itself to be a promising strategy for effective drug delivery into the brain, addressing the frequently arising complications with blood-brain barrier crossing. This study compared the drug adsorption ability and the surface chemistry of two types of silicon nanoparticles (Si-NPs). Si- NPs were prepared using two methods: electrochemical etching of Si wafers (Si-E) and low-pressure plasma synthesis (Si-P). Silicon nanoparticles were characterized by X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD) and nitrogen physisorption (method of Barrett, Joyner, and Halenda (BJH) and method of B.. View more»