Journal of Carcinogenesis & Mutagenesis

Department of Oncology, Joseph Carreras Leukaemia Research Institute, Badalona, Spain

Biography

Dr. Javier S Castresana is an professor in the Department of Oncology, Josep Carreras Leukaemia Research Institute, Bardalona, Spain. He is studying several genes involved in different aspects of stem cell activation, including some that encode for multidrug resistance transporters, and others that regulate self-renewal and differentiation. He has been the President of the Iberian Society for Cytometry (SIC) since 2007. He finally joined the IJC at the beginning of 2015.

Publications

• Research Article   
  The Role of Side Population Cells and Hypoxia in Resistance to Chemotherapy in Astrocytoma Cell Lines
  Author(s): Jana Balbuena, Javier S Castresana* and Jordi Petriz*
  
  The objective of this work focuses on determining whether there are tumor cells with the Side Population phenotype in cell lines derived from astrocytomas, and if they are sensitive to hypoxia conditions and to the combination of temozolomide with inhibitors of sonic hedgehog pathway (cyclopamine) and of MGMT (O6 -benzylguanine). Cytometry studies were performed to separate the SP cell fraction in all cell lines. The proportion of SP cells was directly proportional to the degree of malignancy of the astrocytoma. The cells showed characteristics of tumor stem cells, such as a greater capacity for self-renewal, and constituted an independent or partially overlapping population with the population of CD133+ cancer stem cells. SP cells were highly resistant to temozolomide, while tumor cells that did not display tumor stem cell properties appeared to be more sensitive. The soni.. View more»
  

  DOI: 10.35248/2157-2518.21.12.361

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