Department of Cardiology and Vascular Disease, Colmar Hospital, Colmar, France
Research Article
Pharmaco-Mechanical Catheter-Directed Deep Venous Thrombolysis in Phlegmasia Cerulea Dolens: A Monocentric Retrospective Study of 32
Patients between 2013 and 2020
Author(s): John Philippe* and Nirvan Issur
Background: Phlegmasia Cerulea Dolens (PCD) is a rare form of deep venous thrombosis leading to a massive
edema creating an obstruction of the arterial flow resulting in varying degree of arterial ischemic damage. In addition
to the acute risks, there are important long-term complications. Recently some studies have shown that systemic
anticoagulation accompanied by Pharmaco-Mechanical Catheter-Directed (P-CDT) deep venous thrombolysis has to
be the first-line treatment for patients with PCD.
Methods: We report a series of 32 patients in our regional hospital presenting a phlegmasia cerulea dolens and
treated by pharmaco-mechanical catheter-directed deep venous thrombolysis using Recombinant Tissue Type
Plasminogen Activator (r-TPA; Actilyse) accompanied with systemic anticoagulation, between 2013 and 2020.
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