Journal of Neonatal Biology

Department of Gynecology and Pediatrics, Medical Center in Jackson, Mississippi, USA

Publications

• Research Article   
  Newborn Liver Functions as an Adjunct Biomarker in Timing Fetal Neurologic Injury
  Author(s): Jonathan K Muraskas*, Pele Dina, Bianca Di Chiaro, Brendan M Martin, Sachin C Amin and John C Morrison
  
  Background: We hypothesized that in the presence of an intrapartum hypoxic ischemic insult, redistribution of cardiac output away from the hepatic circulation will result in unique patterns of hepatic dysfunction dependent on the degree and duration of the hypoxic ischemic insult. We evaluated the rise and clearance of Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) in term newborns with three common patterns of hypoxic ischemic encephalopathy as an adjunct biomarker in timing of fetal neurologic injury. Methods: We identified 230 term newborns with image proven hypoxic ischemic encephalopathy with profound neurologic impairment over a 30 year period from multiple institutions. Eighty four had liver transaminases in the first 72 hours of life to evaluate patterns of rise and clearance. Results: .. View more»
  

  DOI: 10.35248/2167-0897.20.9.273

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