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Jingqun Tang
Department of Neurology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
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Research Article
Differential Transcription Profiling in Bone Marrow Mononuclear Cells between Myasthenia Gravis Patients with or without Thymoma
Author(s): Jingqun Tang, Ziming Ye, Yi Liu, Mengxiao Zhou and Chao Qin*
Purpose: Defective stem cells have been recognized as being associated with autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis, autoimmune cytopenias and Myasthenia Gravis (MG). However, the differential gene expression profile of Bone Marrow Mononuclear Cells (BMMCs) and the molecular mechanisms underlying MG pathogenesis have not been fully elucidated. Therefore, we investigated the abnormal expression and potential roles and mechanisms of mRNAs in BMMCs among patients with MG with or without thymoma. Methods: Transcription profiling of BMMCs in patients with MG without thymoma (M2) and patients with thymoma-associated MG (M1) was undertaken by using high-throughput RNA sequencing (RNA-Seq), and diseaserelated differentially expressed genes were validated by quantitative real-time polymerase chain r.. View more»