Journal of Clinical and Medical Sciences

Department of Medicine, Biomedical Science, and Surgery, Joan C Edwards School of Medicine, Marshall University, Huntington, United States of America

Publications

• Research Article   
  pNaKtide Inhibits Na/K-ATPase Signaling and Attenuates Obesity
  Author(s): Komal Sodhi*, Kyle Maxwell, Yanling Yan, Jiang Liu, Muhammad A Chaudhry, Zijian Xie and Joseph I Shapiro
  
  Obesity is a growing public health crisis across the world and has been recognized as an underlying risk factor for metabolic syndrome. Growing evidence demonstrates the critical role of oxidative stress in the pathophysiological mechanisms of obesity and related metabolic dysfunction. As we have established previously that Na/K-ATPase can amplify oxidative stress signaling, we aimed to explore the effect of inhibition of this pathway on obesity phenotype using the peptide antagonist, pNaKtide. The experiments performed in murine preadipocytes showed the dose-dependent effect of pNaKtide in attenuating oxidant stress and lipid accumulation. Furthermore, these in vitro findings were confirmed in C57Bl6 mice fed a high-fat diet. Interestingly, pNaKtide could significantly reduce body weight, ameliorate systemic oxidative and inflammatory milieu and improve insuli.. View more»
  

  DOI: 10.35248/2593-9947.23.7.238

  Abstract HTML PDF