Journal of Clinical & Experimental Pharmacology

Robley Rex Louisville VA Medical Center, Louisville, Kentucky

Biography

Jane Frimodig is currently working as a Department of Pharmacology, University of Louisville, USA; he extended his valuable service in field of Pharmacology and Toxicology for several years and has been a recipient of few awards and grants. His research interests reflect in his wide range of publications in various national and international journals.

Publications

• Research Article   
  Efficacy of Thiamine and Medical Management in Treating Hyperuricemia in AUD Patients with ALD: Role of Hyperuricemia in Liver Injury, Gut-Barrier Dysfunction, and Inflammation
  Author(s): Vatsalya Vatsalya*, Fengyuan Li, Jane Frimodig, Nihar Shah, Amar Sutrawe and Wenke Feng
  
  Background: Hyperuricemia has been reported in liver injury; however its role in the early stage of Alcohol-associated Liver Disease (ALD) has not been examined yet. This study investigated the role of Serum Uric Acid (SUA) in alcohol-related liver disease, gut barrier dysfunction, and inflammation activity. This study also evaluated the efficacy of abstinence, treatment with thiamine and medical management to alleviate hyperuricemia. Methods: 48 heavy drinking Alcohol Use Disorder (AUD) patients (34 males [M]/14 females [F]) participated in this study. Patients were grouped by serum Alanine Aminotransferase (ALT) levels as group 1 (ALT ≤ 40 U/L, 7M/8F) and group 2 (ALT>41U/L, 27M/6F). All patients received open label thiamine 200 mg daily dose. Demographics, drinking history (using Lifetime Drinking History [LTDH], an.. View more»
  

  Abstract HTML PDF