Journal of Blood Disorders & Transfusion

Department of Thrombosis and Vascular Diseases Laboratory, RMIT University, Bundoora, Victoria, Australia

Publications

• Review Article   
  Next Generation Sequencing of Human Red Cell Antigens Kell, Kidd, and Duffy for Routine Clinical Investigations and Donor Screening: A Systematic Review and Meta-Analysis
  Author(s): Hua HC and Jackson DE*
  
  The emergence of Next-Generation Sequencing (NGS) allows replacement over current molecular testing for red cell antigens in routine practice of transfusion laboratories in determining individual phenotypes. The high throughput platforms enhance the likelihood of donor matching by extended blood group genotyping and meanwhile explore novel and rare polymorphisms, potentially assisting in large-pooled donor screening and well-typed inventory build- up in blood banks. To reconcile NGS application in this field, this systematic review and meta-analysis of the literature was conducted to examine whether NGS has adequate grounds to replace current SNV-based genotyping. Overall, 362 samples in 6 eligible studies were studied upon screening through inclusion/exclusion criteria. Concordance analyses between NGS platforms and serology or other molecular typing methods on K.. View more»
  

  DOI: 10.4172/2155-9864.23.14.552

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